Certificate Signature field is generated at the time it was created by Certificate Issuer. The process is:
HashCertificate Issuer's Public Key Certificate Exponent/MOD(Certificate Issuer's Public Key Certificate Modulus value)
Since the Certificate Issuer's Public Key is available to all, for Certificate Validation we can perform these same steps and calculate the value. The calculated value should match the value on the Protocol Server's Certificate.